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Although uncommon, its incidence has been on the rise for the past decades, possibly due to the increased sexual transmission of human papilloma virus HPV 2 - 6. More recently, combined modality therapy with radiation RT and concurrent chemotherapy has emerged as the preferred method of treatment price topamax squamous cell cancer SCC of the anal canal, which has significantly reduced the rates of locoregional recurrence and obviated the need for a permanent colostomy in most cases 10, However, no randomized trials in anal canal cancer have so far compared 5-FU and capecitabine. A non-randomized phase II trial of 31 patients has explored the use of capecitabine, mitomycin and RT in anal cancer patients.

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