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Tegretol carbamazepine is an anticonvulsant and specific analgesic for trigeminal neuralgia. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. Tegretol greatly reduces or abolishes pain induced by stimulation of the infraorbital nerve in cats and rats. It depresses thalamic potential and bulbar and polysynaptic reflexes, including the linguomandibular reflex in cats.
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ABSTRACT: Trigeminal neuralgia TGN is a sudden onset, short-duration, yet debilitating neuropathic pain arising from the compression of the fifth cranial nerve, precipitated by daily activities such as chewing and speaking. This chronic condition is most common in older females, affecting up to 27 per, individuals cost of oral zyvox. The first-line pharmacologic treatment for TGN is the anticonvulsant carbamazepine, with oxcarbazepine utilized for its similar mechanism but milder adverse-effect profile. Second-line drug therapies baclofen, lamotrigine are considered useful adjuncts, with less-well-studied medications or surgery reserved if standard treatment alone is ineffective or not tolerated by the patient.
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