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A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine.
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Mestinonpyridostigmine bromideis a drug commonly used for treating myasthenia gravisThe drug is currently under investigation for spinal muscular atrophySMA. Acheter generic mestinon england.
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Authored by Dr. Sandip Chander, OD