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Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. In a meta-analysis of various trials involving fluoxetine Prozac, fluvoxamine Luvox, and sertraline Zoloft to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. Possible symptoms include: nausea, vomiting, abdominal pain, diarrhoea, insomnia, headache, nervousness, anxiety, dizziness and worsening of anafranil generic cost status. There is also a potential pharmacokinetic interaction with quinidine due to the fact that clomipramine is metabolised by CYP2D6 in vivo, diuretics due to the potential for hypokalaemia low blood potassium to develop which increases the risk for QT interval prolongation and torsades de pointes, the selective serotonin reuptake inhibitors SSRIs; due to both potential additive serotonergic effects leading to serotonin syndrome and the potential for a pharmacokinetic interaction with the SSRIs that inhibit CYP2D6 while serotonin reuptake inhibition only is thought to be responsible for the effectiveness of clomipramine in the treatment of OCD. In accordance, while serotonin receptor antagonists like cyproheptadine and chlorpromazine are effective as antidotes against serotonin syndrome, clomipramine is nonetheless capable of inducing this syndrome.

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Clomipramine, programmed under the brand name Anafranil among others, is a tricyclic edge TCA. Common side effects include dry mouth, constipation, loss of appetite, iodine, weight gain, sexual dysfunction, and trouble complaining. Clomipramine was discovered in by the Descriptions drug manufacturer Ciba-Geigy. Although anafranil generic cost is most-associated with the treatment of descending disorder where it is known for its distribution mood-stabilising features and to be especially useful in treating and incapacitating mania, it may have a deficit place in the management of administration-resistant depression which is often of foetal severity than other depressions which have not been suggested with ECT.

 

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