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The usual dosage range is 20 to 40 mg per day administered in a single daily dose.
It is used to treat depression and generalized anxiety disorder. For depression and anxiety, duloxetine works by affecting the balance of chemicals in the brain and other parts of the body. For certain types of pain, duloxetine works by affecting the balance of chemicals in the brain and spinal cord that are involved in the experience of pain. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
The clinician should, nevertheless, be aware of the possibility of emergent symptoms of serotonin syndrome with such use see Warnings and Precautions 5. Other brands: Drizalma Sprinkle, Irenka. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dosing in Special Populations Hepatic Impairment — Avoid use in patients with chronic liver disease or cirrhosis see Warnings and Precautions 5. Serotonin-norepinephrine reuptake inhibitors.
Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. The 60 mg capsules also contain iron oxide yellow. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors in vitro. Duloxetine does not inhibit monoamine oxidase MAO. No QT interval prolongation was detected. In all of these clinical trials, analyses of the relationship between treatment outcome and age, gender, and race did not suggest any differential responsiveness on the basis of these patient characteristics. In Studies GAD-1 and GAD-2, the starting dose was 60 mg once daily down titration to 30 mg once daily was allowed for tolerability reasons; the dosage could be increased to 60 mg once daily.
Capsule 28pcs. Home delivery within 2 hours Free Delivery Above If you have severe kidney disease. If you are taking or have taken within the last 14 days a monoamine oxidase inhibitor MAOI. If y are taking Fluvoxamine, Ciprofloxacin or Enoxacin. Warnings and precautions: Talk to your doctor about all your medical conditions before taking this medicine including: If you are taking other medicines to treat depression.
Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Duloxetine was approved for medical use in the United States in Duloxetine is recommended as a first-line agent for the treatment of chemotherapy-induced neuropathy by the American Society of Clinical Oncology, as a first-line therapy for fibromyalgia in the presence of mood disorders by the German Interdisciplinary Association for Pain Therapy, as a Grade B recommendation for the treatment of diabetic neuropathy by the American Association for Neurology and as a level A recommendation in certain neuropathic states by the European Federation of Neurological Societies. Food and Drug Administration approved duloxetine to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain. In 4 clinical trials of duloxetine for the treatment of MDD, sexual dysfunction occurred significantly more frequently in patients treated with duloxetine than those treated with placebo, and this difference occurred only in men.
It is very important that you take the medicine at about the same time every day. It will work best if you do this. It is important that you keep taking each dose of this medicine on time even if you are feeling well. If you forget to take a dose cymbalta 60 mg time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose.
Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Cymbalta duloxetine hydrochloride is an antidepressant in the serotonin-norepinephrine reuptake inhibitor SNRI category. It is taken by mouth, as cymbalta 60 mg pill or capsule, and can be prescribed for certain depression and anxiety disorders. We also discuss how to take Cymbalta safely, which involves knowing its precautions and contraindications, as well as its potential side effects.
A small number of children, teenagers, and young adults up to 24 years of age who took antidepressants ''mood elevators'' such as duloxetine during clinical studies became suicidal thinking about harming or killing oneself or planning or trying to do so. Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions.
Author: Eli Lilly Nederland B. Your doctor may continue to give you Cymbalta when you are feeling better to prevent your depression or anxiety from returning.
For some patients, consider starting at 30 mg qDay for 1 week, to allow patients to adjust to medication before increasing to 60 mg qDay. Treatment of chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain.
All FDA black box warnings are at the end of this fact sheet. Duloxetine is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder MDD, generalized anxiety disorder GAD, diabetic peripheral neuropathic pain DPNP, fibromyalgia, and chronic musculoskeletal pain. Generalized Anxiety Disorder GAD occurs when a person experiences excessive anxiety or worry for at least six months. Do not stop taking duloxetine, cymbalta 60 mg when you feel better.
Duloxetine, sold under the brand name Cymbalta among others, 1 is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Duloxetine is a serotonin—norepinephrine reuptake inhibitor SNRI. Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Duloxetine was approved for medical use in the United States and in the European Union in The main uses of duloxetine are in major depressive disorder, generalized anxiety disorder, neuropathic pain, chronic musculoskeletal pain, and fibromyalgia.