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Mild to moderate swelling might occur in about 10 percent of people taking nifedipine. Most pregnancies last about 40 weeks, but about one in eight births in the U. Those preterm babies are more likely to have serious illnesses or die than full-term buys nifedipine, and they're at higher risk for learning and developmental disabilities. What is the evidence for the use of nifedipine for preterm labor? In addition, calcium-channel blockers were associated with fewer women discontinuing treatment because of side effects.
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Peripheral edema buildup of fluid in the ankles, feet and legs. But the authors questioned the importance of that complication because it did not appear to affect the fetus. Zuspan Professor and endowed chairman in the division of maternal fetal medicine at Ohio State University. Nifedipine has been found to interact with beta-blockers and other medication including digoxin Cardoxin, Digitek, Lanoxicaps, Lanoxin, quinidine, warfarin Coumadin, cimetidine Tagamet, and magnesium sulfate.
Nifedipine is approved to control high blood pressure and angina chest pain. That's why obstetricians have a growing interest in nifedipine Adalat, Procardia, and generics, a medicine that appears to cause fewer side effects than some other tocolytics, although it has been found to also produce some serious adverse effects. But nifedipine is associated with an increased risk of angina, heart attack, congestive heart failure, irregular heart rhythm, oxygen deficiency in the tissues hypoxia, and renal failure.
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Nifedipine is a dihydropyridine calcium antagonist that lowers BP by peripheral vasodilatation with only mild negative inotropic and chronotropic effects. From: Comprehensive Hypertension, Messerli, in Comprehensive Hypertension, The advantages of nifedipine use are rapid onset of action and lack of central nervous system depression. Nifedipine is the most extensively studied agent for rapid control of BP, and until was used for acute BP lowering in hospitalized patients. After sublingual administration, the onset of action is within 1 to 5 minutes with a maximal effect at 20 to 30 minutes.
Authored by Dr. Michael Terrance Havig, MD