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Sukhmanjeet Kaur Mann ; Raman Marwaha. Chlorpromazine is a medication used to manage and treat schizophrenia, bipolar disorder, and acute psychosis. Objectives: Identify the mechanism of action of chlorpromazine. Describe the potential adverse effects of chlorpromazine. Outline the importance of monitoring patients on chlorpromazine and describe the symptoms of the toxicity.
While the pursuit of new medications and somatic interventions should be maintained, psychiatrists must also use the existing evidence base developed over the decades and synthesize new integrated models of care that tackle a mood disorder from multiple angles. Nonpharmacological, evidence-based cognitive and behavioral therapies also emerged during this time, as did safer protocols for electroconvulsive therapy ECT, providing two more avenues of treatment. From this frustration came the appreciation that while monoamine theory was an important aspect of mood disorder pathophysiology, it was but one part of a bigger story. The complexity of these disorders arose from a multitude of genetic, developmental, hormonal, social, and environmental factors that evolve and change across the lifespan. Furthermore, diagnosis and management of mood disorders requires integration of the existing evidence-based treatments with new, multidisciplinary team approaches ensuring continuity of care.
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Authored by Dr. Javier P Berrios, MD