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These drug combinations should not be used are contraindicated in patients with diabetes. A list of medicines containing aliskiren is found in the Drug Facts box. The preliminary data from ALTITUDE also demonstrated a slight excess of cardiovascular events death or stroke in the aliskiren group see Data Summary ; however, FDA has reached no definite conclusion regarding an actual link between these drugs and death or stroke. ALTITUDE was terminated early for lack of efficacy and because risks of renal impairment, hypotension, and hyperkalemia were observed to be greater in diabetic patients treated with aliskiren than in patients treated with placebo. The purpose of ALTITUDE was to determine whether aliskiren compared to placebo, on top of conventional treatment, reduces death and disease caused by the heart, the circulatory system and the kidney. In an FDA analysis of data from U. Facts about aliskiren-containing products.

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