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Serotonin—norepinephrine reuptake inhibitors SNRIs are a class of antidepressant drugs that treat major depressive disorder MDD, anxiety disorders, obsessive—compulsive disorder OCD, social phobia, attention-deficit hyperactivity disorder ADHD, chronic neuropathic pain, fibromyalgia syndrome FMS, and menopausal symptoms. These neurotransmitters are thought to play an important role in mood regulation. The human serotonin transporter SERT and norepinephrine transporter NET are membrane transport proteins that are responsible for the reuptake of serotonin and norepinephrine from the synaptic cleft back into the presynaptic nerve terminal. Dual inhibition of serotonin and norepinephrine reuptake can offer advantages over other antidepressant drugs by treating a wider range of symptoms.

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