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Selegiline, also known as L -deprenyl and sold under the brand names Eldepryl and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. Selegiline acts as a monoamine oxidase inhibitor, and increases levels of monoamine neurotransmitters in the brain. At typical clinical doses used for Parkinson's disease, selegiline is a selective and irreversible inhibitor of monoamine oxidase B MAO-B, increasing levels of dopamine in the brain. Selegiline has also been used off-label as a palliative treatment for dementia in Alzheimer's disease.
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Authored by Dr. Nicole S Boxer, MD