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A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein. Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium. An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions. Molfile Molfile Molfile expand. Mycoplasma genitalium NCBI:txid

Lineu Prestes, ; ; sferraz usp. Chloramphenicol is a large spectrum antibiotic with antimicrobial activity. Its mechanism of action is based on the inhibition of protein synthesis; however, the resistance of gram-positive and gram-negative microorganisms in vivo is a clinical problem of increasing importance Kapusnik-Uner et al. Chloramphenicol is available for oral administration as chloramphenicol palmitate - a prodrug of chloramphenicol - developed with the objective of a more pleasent flavored derivative. Chloramphenicol palmitate is quickly and almost completely hydrolyzed by intestinal esterase, being distributed widely throughout corporal liquids and quickly achieving therapeutic levels Singhal and Curatolo, Therapy with chloramphenicol should be limited to infections where the benefit of the drug exceeds the risk of potential toxicity Kapusnik-Uner et al.

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Wilcox, in Antibiotic and Chemotherapy Ninth Edition, The plasma concentration achieved is proportional to the dose administered. Pancreatic lipase is deficient in neonates and, because of poor hydrolysis, the palmitate should be avoided. Protein binding is reduced in cirrhotic patients and neonates, with correspondingly elevated concentrations of free drug. Extraintestinal translocation of colonic mucosa into regional lymph nodes and liver. Lawsonia intracellularis is sensitive to chloramphenicol.

Chloramphenicol Palmitate is a hexadecanoate ester which derives from Chloramphenicol. It is a order chloromycetin palmitate, white crystalline powder which is odorless. Chloramphenicol Palmitate can be used in different dosages as chew treats, oral oil suspension, oral paste and oral tropical gel. Chloramphenicol palmitate is a drug with serious toxicities. This chemical is therefore recommended only to treat serious infections in which less toxic antibacterials are ineffective or contraindicated.

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Brij Bhumi Complex, Nagpur No. Ansar Nagar, Nagpur Plot No. Prabhadevi, Mumbai Office No. Verified Supplier Company Video. Uses Chloramphenicol is used in the order chloromycetin palmitate of bacterial infectionsIt is used to. This includes use as an eye ointment to treat conjunctivitis.

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United States Patent Nakamura et al. Limited, Osaka, Japan 22 Filed: Dec. Meyers Assistant ExaminerDaren M. The dispersing agents to be used in this invention may be any of those for pharmaceutical uses such as, polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropylcellulose, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, gum arabic, carboxyvinyl polymer, polyethylene glycols, propylene glycol, sorbitan fatty order chloromycetin palmitate esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene castor oil derivatives, glyceryl fatty acid esters, sucrose fatty acid esters, alkyl sulfates, dialkylsulfosuccinates and fatty acid sarcosinates, etc. The surface active agents to be used here may be any of those for pharmaceutical uses such as, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene castor oil derivatives, glyceryl fatty acid esters, sucrose fatty acid esters, alkyl sulfates, dialkylsulfosuccinates and fatty acid sarcosinates. In the case of obtaining chloramphenicol palmitate preparation fitted to that object, it is very important to get a preparation wherein the palmitate is contained in the.

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