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Objective: To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Procedure: Cats with a minimum 1-month history of spraying urine against vertical surfaces at least twice per week were randomly assigned to be treated with a placebo or with clomipramine at a dosage of 0. Results: Prior to treatment, mean number of urine spraying events ranged from 0. All 3 dosages of clomipramine were associated with significant reductions in frequency of urine spraying. Sedation was the most common adverse effect and was identified in 27 of the 50 cats treated with clomipramine; however, treatment was not discontinued in any cat because of sedation.

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