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Therefore the only time we can supply an increased quantity of a prescribed medicine is if the doctor prescribes that quantity for you.
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Nature Medicine August 28; 24 AHF is one of the leading primary diagnoses for hospitalization, with an estimated 1 million US patients discharged in Therefore, treatment of AHF is directed toward achieving adequate decongestion using various combinations of diuretics. Loop diuretics are most commonly used as they eliminate extracellular sodium and water from the body; extracellular sodium excess can drive volume overload and congestion Mullens W, Eur J Heart Fail Despite high-dose loop diuretics, many patients are discharged from the hospital with residual volume overload. As nephrologists, we are often concerned about overly aggressive diuresis leading to intravascular volume depletion and worsening renal function, especially if diuresis occurs at a rate greater than the extravascular fluid can refill the intravascular space. Despite this relationship, hemoconcentration and even a rising creatinine have been associated with substantial improvement in patient survival. These observations raise the question of whether aggressive decongestion can positively affect patient mortality and other outcomes Testanti JM et al. An even more basic is the question: what is the best marker for adequate diuresis? Is it a change in body weight?
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