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It works by slowing the central nervous system to allow muscles to relax. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur.
Structurally, tizanidine is similar to clonidine, but only to as potent for lowering blood pressure. Elliott, in Current Therapy in Pain, Tizanidine had been used predominantly in the management of spasticity; however, it has also proved useful for a variety of painful conditions. As to its efficacy in the management of spasticity, tizanidine compares favorably with both baclofen and and seems to cause less muscle weakness than baclofen and a lower incidence of sedation than. It appears that muscle strength is fairly well preserved in patients taking tizanidine for spasticity or muscle spasm, because less weakness is associated with use of this drug compared with baclofen or. Tizanidine has been successfully used in the treatment of paravertebral muscle spasm in association with acute low back pain as well and is frequently employed in the management of myofascial pain. Another major indication for the use of tizanidine is in the management of headache disorders.
It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It was patented in and came into medical use in It is licensed in the UK as 0. It is sold in Poland as Noctofer. Lormetazepam is considered a hypnotic benzodiazepine and is officially indicated for moderate to severe insomnia. Lormetazepam is a short-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep or falling asleep. Hypnotics should only be used on a short-term basis or, in those with chronic insomnia, on an occasional basis. Side effects of lormetazepam are similar to those of other hypnotic benzodiazepines and can for the most part be regarded as a class effect. Benzodiazepines require special precaution if used during pregnancy, in children, in alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.
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As with other benzodiazepines, should be avoided in patients with pulmonary disease if possible. should be avoided if possible in patients with respiratory depression severe chronic obstructive pulmonary disease COPD, or sleep apnea because the drug can exacerbate ventilatory failure. In rare instances, death has occurred in patients with severe pulmonary disease shortly after the initiation of. Oral benzodiazepine used for the management of anxiety including panic disorder; relatively shorter half-life and absence of active metabolites; potential for significant CYP3A4 interactions. Use the lower dose for debilitated adults initially. If discontinuation becomes necessary, the manufacturer suggests that the daily dose be decreased by no more than 0.
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, zanaflex 1mg 2.5mg epilepsy, and absence seizures, although tolerance may develop Label 11, 12, 13, The agent has also been indicated for treating panic disorder Label 7, 11, 12, 13, The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses Label 7, 8, 11, 12, 13, Since being first patented in and then released for sale from Roche in the US in 9, 10, has experienced a storied history in the treatment of the aforementioned medical conditions. Unfortunately, however, like most benzodiazepines, use has also been associated with recreational use and drug abuse Label 11, 12, 13, A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Tizanidine is a central alphaadrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with Tizanidine should be reserved for those daily activities and times when relief of spasticity is most important, mammalian gene mutation, and chromol aberration test in mammalian cells and in vivo bone marrow micronucleus, and cytogenetics assay. Single-Dose Study in Patients with Multiple Sclerosis with Spasticity In Study 1, patients with multiple sclerosis were randomized to receive single oral doses of drug or placebo. Patients and assessors were blind to treatment assignment and efforts were made to reduce the likelihood that assessors would become aware indirectly of treatment assignment e. In all, patients received placebo, 8 mg or 16 mg of Tizanidine.
Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine.
Sun Pharmaceutical Industries Ltd. Product introduction Tizan 2 Tablet is a muscle relaxer.
Take this medicine only as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered.
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