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The effect of ezetimibe on cardiovascular morbidity and mortality has not been determined. Ezetimibe, administered alone or in combination zetia mail order a statin, is indicated as adjunctive therapy to diet for the reduction of elevated total cholesterol, LDL cholesterol, apolipoprotein B, and non—high-density lipoprotein HDL cholesterol in patients with primary heterozygous familial and nonfamilial hyperlipidemia when diet alone is not enough. Sources: Merck ; February 15, ; and Merck ; June 3, Agency rejects use in reducing cardiovascular risk in heart disease patients. Despite older, sicker patients, mortality rate fell by a third in 10 years.
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Ezetimibe is used alone or in combination with other antilipemic agents i. Efficacy of ezetimibe, alone or in fixed combination with simvastatin, in patients with Fredrickson type I, III, IV, or V dyslipidemias has not been established. Drug therapy is not a substitute for but an adjunct to these nondrug therapies and measures, which should be continued when drug therapy is initiated. However, nonstatin drugs may be useful as adjuncts to statin therapy in high-risk patients e. When a nonstatin drug is required, selection of the nonstatin drug should be based on a favorable benefit-risk ratio i.
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