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Current treatments for obstructive sleep apnoea OSA are not tolerated or effective in a proportion of patients. Other therapeutic options are needed; pharmaceuticals may provide an alternative. This randomised, double-blind, placebo-controlled, cross-over study examined the effect of combination acetazolamide and dronabinol IHLX at low, medium and high doses on OSA severity. The change from baseline in AHI, oxygen desaturation index ODI, Epworth sleepiness score ESS, and mood profile of mood states on the final night of each treatment arm relative to placebo were the major endpoints. Adverse events AEs were monitored throughout.

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