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Duloxetine is a type of antidepressant medicine known as a serotonin-noradrenaline reuptake inhibitor SNRI. SNRIs are thought to work by increasing the amount of mood-enhancing chemicals, serotonin and noradrenaline, in your brain. It's used to treat depression and anxiety. It's also used to treat nerve pain, such as fibromyalgia, and can be used to treat stress urinary incontinence in women. Duloxetine comes as capsules.