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Discontinuing an antidepressant medication usually involves reducing your dose in increments, allowing two to six weeks or longer between dose reductions. Your clinician can instruct you in tapering your dose and prescribe the appropriate dosage pills. In some cases, you can use a pill cutter to create smaller-dose pills, though be sure to check with your clinician or pharmacist to find out if your antidepressant can be cut. Your tapering schedule will depend on which antidepressant you're taking, how long you've been taking it, your current dose, and any symptoms you had during previous medication changes. However, depending on how you respond to each dose reduction, you may want to taper more gradually using smaller dose reductions, longer intervals between dose reductions, or both. If you experience discontinuation symptoms after a particular dose reduction, you may want to add back half the dose — or all of it — and continue from there with smaller dose reductions. There are no hard and fast rules for getting off antidepressants, other than that the approach should be individualized!

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However, the final decision will always be the prescriber's. Duloxetine is used for the treatment of depression and anxiety. It is also used to help relieve nerve pain in diabetic individuals or ongoing pain due to medical conditions such as chronic back pain, arthritis, or fibromyalgia. Duloxetine may improve your mood, appetite, and energy level. It may also decrease nervousness and help decrease pain due to certain medical conditions.

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