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Patients on EMSAM experienced a significantly longer time to relapse than those in the placebo group. When applied to intact skin, EMSAM is designed to transdermally deliver selegiline over a hour period. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors. EMSAM is contraindicated in patients less than 12 years of age because of an increased risk of hypertensive crisis. The mechanism of action of selegiline the drug substance of EMSAM as an antidepressant is not fully understood, but is presumed to be linked to potentiation of monoamine neurotransmitter activity in the central nervous system CNS resulting from its irreversible inhibition of the enzyme MAO. Transdermal dosing results in significantly higher exposure to selegiline with significantly lower exposure for all metabolites.

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Your biology is only the beginning. Select a medication from the dropdown below Lactic acidosis is a medical emergency and requires immediate treatment in the hospital. Talk to your healthcare provider if you are planning to become pregnant or if pregnant or breastfeeding. Avoid alcohol while taking this medication. These symptoms may subside after the body adjusts to the medication.

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ANIPRYL selegiline hydrochloride is indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome CDS and control of clinical signs associated with uncomplicated canine pituitary dependent hyperadrenocorticism PDH. Initially, dogs should be dosed to the nearest whole tablet. Adjustments should then be made based on response and tolerance to the drug. If no improvement is observed after 2 months of therapy, dosage may be increased to a maximum of 2. If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated. In dogs whose clinical signs of PDH progress despite Anipryl therapy in the absence of concurrent disease, alternate therapy should be considered.

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