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Lisinopril is used alone or in combination with other classes of antihypertensive agents e. Because captopril, another angiotensin-converting enzyme ACE inhibitor, may cause serious adverse effects, e. Lisinopril is used alone or in combination with other classes of antihypertensive agents in the management of hypertension. ACE inhibitors are considered one of several preferred antihypertensive drugs for the initial management of hypertension; other options include angiotensin II receptor antagonists, calcium-channel blockers, and thiazide diuretics. While there may be individual differences with respect to specific outcomes, these antihypertensive drug classes all produce comparable effects on overall mortality and cardiovascular, cerebrovascular, and renal outcomes. In general, black hypertensive patients tend to respond better to monotherapy with thiazide diuretics or calcium-channel blockers than to monotherapy with ACE inhibitors.

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Ernst, clinical professor at the University of Iowa College of Pharmacy and researcher on blood pressure variability, told Healthline. Therefore, they are not usually used as a monotherapy, but are usually reserved for adding to other antihypertensives when the existing regimen fails to achieve the goal blood pressure. Prior research from revealed a link between large variations in blood pressure and increased mortality risk. Then, during the American College of Cardiology Scientific Session, researchers warned that alpha-blockers and alpha-2 bumex 2.5mg olanzapine were more associated with blood pressure variability than other commonly used medications. According to researchers, that variation in blood pressure was linked to an increased risk of death.

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