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Adverse effects, dry mouth, sedation and drowsiness, can be severe, limiting the usefulness of these two drugs. Adrenergic neurone blockers are used rarely to treat hypertension that is resistant to other drugs. They block release of noradrenaline at sympathetic nerve endings and therefore cause vasodilation and reduced peripheral vascular resistance. An example of an adrenergic neurone blocker is guanethidine.
Authored by Dr. Nancy Jane Hamilton, DDS