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Acetylcholinesterase is the enzyme that is the primary member of the cholinesterase enzyme family. Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. These residues mediate the hydrolysis of the acetylcholine. This acetylated state requires hydrolysis to regenerate itself. Therefore the acetylcholine will remain intact and will accumulate in the synapses.

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