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Language: English Spanish French. Knowledge of pharmacotherapeutic treatment options in obsessive-compulsive disorder OCD has grown considerably over the past 40 years. Serotonergic antidepressants, such as selective serotonin reuptake inhibitors SSRIs and clomipramine, are the established pharmacologic first-line treatment of OCD. Medium to large dosages and acute treatment for at least 3 months are recommended until efficacy is assessed. In case of significant improvement, maintenance treatment is necessary.
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