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Topamax topiramate is an anticonvulsant prescribed for preventing epileptic seizures and migraine headaches. Topamax is available as a generic drug. Drug interactions include acetazolamide Diamox, methazolamide Neptazane, dichlorphenamide Daranide, carbamazepine Tegretol and phenytoin Dilantin and oral contraceptives. There are no adequate studies of Topamax in pregnant women and it is not known if Topamax is secreted in human breast milk. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus.
Topiramate is a new antiepileptic drug, originally designed as an oral hypoglycaemic subsequently approved as anticonvulsant. Topiramate is a sulfamate substituted, derivative of the monosaccharide D-fructose. It pharmacokinetic profile is linear in relation to dose. It does not affect liver enzymes, it is excreted unchanged in the urine, and has a high therapeutic index. In renal impairment, the clearance of topiramate is decreased and elimination half-life is prolonged, usually between 19 and 23 hours.
Monotherapy in adults, adolescents and children over 6 years of age with partial seizures with or without secondary generalised seizures, and primary generalised tonic-clonic seizures. Adjunctive therapy in children aged 2 years and above, adolescents and adults with partial onset seizures with or without secondary generalization or primary generalized tonic-clonic seizures and for the treatment of seizures associated with Lennox-Gastaut syndrome. Topiramate is indicated in adults for the prophylaxis of migraine headache after careful evaluation of possible alternative treatment options. Topiramate is not intended for acute treatment. It is not necessary to monitor topiramate plasma concentrations to optimize therapy with Topamax. On rare occasions, the addition of topiramate to phenytoin may require an adjustment of the dose of phenytoin to achieve optimal clinical outcome. Addition or withdrawal of phenytoin and carbamazepine to adjunctive therapy with Topamax may require adjustment of the dose of Topamax. In patients with or without a history of seizures or epilepsy, antiepileptic drugs AEDs including topiramate should be gradually withdrawn to minimize the potential for seizures or increased seizure frequency. In paediatric clinical trials, topiramate was gradually withdrawn over a week period. When concomitant AEDs are withdrawn to achieve monotherapy with topiramate, consideration should be given to the effects this may have on seizure control.
Topiramate was approved for medical use in the United States in It is claritin 20 tablets price frequently prescribed for the prevention of migraines as it decreases the frequency of attacks. Other uses include treatment of obesity and antipsychotic -induced weight gain. Adverse effects by incidence Symptoms of overdose may include but are not limited to
This drug is also sometimes given to help prevent migraine headaches from occurring. It works by lessening abnormal excitement topamax 300 mg the brain. You should not use topiramate if you are allergic to it. Do not take within 6 hours before or 6 hours after drinking alcohol. However, having a seizure during pregnancy could harm both the mother and the baby.
Topiramate is an epilepsy drug which is also approved for the preventive treatment of migraine headaches. It is a very popular drug, in part because it can cause weight loss in some patients. In clinical trials only half of migraine patients who started taking this drug remained on it for more than a few months because it was ineffective for some and caused intolerable side effects in others. One of the main side effects which makes people stop taking this drug is difficulty speaking and thinking. Half of the patients who developed kidney stones were not aware of it.
Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. In, Topamax received FDA approval for the prevention of migraines. Manufactured by Janssen Pharmaceuticals, Topamax is now the number-one prescribed medication for migraine prevention in the United States. It's used to stop migraine headaches from occurring in those 12 and older. Doctors occasionally prescribe Topamax off-label to control binging and purging and promote weight loss in people with eating disorders such as bulimia nervosa and binge-eating disorder.
If you become depressed or develop any problems with your eyesight, make an appointment to see your doctor straightaway. In people with migraine, it is thought that some chemicals in the brain increase in activity and, as a result, parts of the brain then send out confused signals which result in the symptoms of headache and sickness.
Orphan designation for Captisol-enabled topiramate injection for the treatment of partial onset or primary generalized tonic-clonic seizures in hospitalized patients with epilepsy or those being treated in an emergency care setting who are unable to take oral topiramate. Increased risk for bleeding; in patients with serious bleeding events, conditions that increased the risk for bleeding were present.
The total daily oral dose is given in 1 to 2 divided doses per day depending on the type of preparation. Available preparations include: Oral immediate release IR dosed twice daily and extended release ER dosed once daily.
Newer antiepileptic drugs may control seizures more effectively, but their significant potential for serious side effects requires a thorough knowledge of the drugs and careful consideration of the risks and benefits. Gabapentin Neurontin has been approved as adjunctive therapy in adults with partial seizures with or without secondary generalization Table 1. Its mechanism of action is unknown. Gabapentin is well absorbed orally, circulates mostly unbound in the plasma and is excreted unchanged in the kidneys without appreciable metabolism in the body. Oral bioavailability is approximately 60 percent and is not affected by food.
I began taking Topamax for partial seizures in January, I have since lost 25 pounds I am 5' 2 and am down to lbs. I just really have no appetite most of the time. I am wondering if others have lost weight like this on Topamax and if so, has the weight stayed off, or did you gain it back? I am 42 years old and was diagnosed with TLE in March of