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Consumers stand to reap big savings when a drug patent expires, freeing other companies to sell generic equivalents. In reality, drugmakers can manipulate the market to maintain higher profits for as long as possible. You can still save—as long as you know how to sidestep the traps. Manufacturer co-pay coupons. Even if a coupon cuts your price at the counter, your employer and insurance company still foot the bill for the full price, and that can cost you in higher premiums later on. Drugmakers sometimes discourage the use of generics by making subtle changes to the branded drug—switching from a tablet to a capsule, for example, or offering a higher or lower dose.
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A panel of experts found Wednesday that Celebrex, or celecoxib, is no less safe than two other non-opioid painkillers. Based on the committee's conclusion, the FDA may change the advice about the drug's safety that it provides to doctors. The availability and safety of alternatives to opioid painkillers have become increasingly important as the nation grapples with the deadly epidemic. For more than a decade, some doctors have been reluctant to prescribe celecoxib, which isn't an opioid, because it is similar to Vioxx, a pain reliever that was withdrawn from the market in because of safety concerns. Both drugs are known as COX-2 inhibitors because they act by blocking an enzyme involved in inflammation. After Vioxx was launched in, it quickly became a blockbuster and was used by millions of people. It was designed to cause fewer gastrointestinal complications than existing pain relievers. But Vioxx was pulled from the market in after being linked to heart attacks and strokes. The FDA allowed Celebrex to remain on the market but ordered to conduct a large study to examine the drug's safety.
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Previous evaluations of the cost-effectiveness of the cyclooxygenase-2 selective inhibitor celecoxib Celebrex, Inc, USA have produced conflicting results. The celebrex cost controversy over the cardiovascular CV risks of rofecoxib and other coxibs has renewed interest in the economic profile of celecoxib, the only coxib now available in the United States. The objective of our study was to evaluate the long-term cost-effectiveness of celecoxib compared with nonselective nonsteroidal anti-inflammatory drugs nsNSAIDs in a population of year-old osteoarthritis OA patients with average risks of upper gastrointestinal UGI complications who require chronic daily NSAID therapy. We used decision analysis based on data from the literature to evaluate cost-effectiveness from a modified societal perspective over patients' lifetimes, with outcomes expressed as incremental costs per quality-adjusted life-year QALY gained. Nonselective nonsteroidal anti-inflammatory drugs nsNSAIDs are widely used to treat acute and chronic pain, including the symptoms of osteoarthritis OA. The cyclooxygenase-2 selective inhibitor celecoxib reduces the risks of nsNSAID-induced gastropathy without compromising clinical efficacy.
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A drug class is a group of medications that work in a similar way. Celebrex contains the active ingredient celecoxib.
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It relieves pain that is caused by arthritis, menstruation and ankylosing spondylitis. It can also be given to treat hereditary polyps in the colon.
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