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Author: Eli Lilly Nederland B. ZYPREXA is used to treat a disease with symptoms such as hearing, seeing or sensing things which are not there, mistaken beliefs, unusual suspiciousness, and becoming withdrawn. People with this disease may also feel depressed, anxious or tense. ZYPREXA is used to treat a condition with symptoms such as feeling high, having excessive amounts of energy, needing much less sleep than usual, talking very quickly with racing ideas and sometimes severe irritability. It is also a mood stabiliser that prevents further occurrences of the disabling high and low depressed extremes of mood associated with this condition. An allergic reaction may be recognised as a rash, itching, a swollen face, swollen lips or shortness of breath.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Olanzapine was initially used orally and intramuscularly for the chronic treatment of schizophrenia in patients over 13 years old and other psychiatric disorders such as bipolar I disorder including mixed or manic episodes. Olanzapine is also indicated, in combination with lithium or valproate for the short-term treatment of acute manic or mixed episodes associated with bipolar I disorder in adults. As well, olanzapine is indicated, in combination with fluoxetine for the treatment of episodes of depression associated with bipolar disorder type 1 and treatment-resistant depression in patients over 10 years old. Olanzapine is also approved for the management of psychomotor agitation associated with schizophrenia and bipolar I mania.

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Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder manic depression in adults and children who are at least 13 years old. Long-term use of olanzapine can cause a serious movement disorder that may not be reversible. Symptoms include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take olanzapine, the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking olanzapine, do not stop taking it without your doctor's advice. Olanzapine can pass into breast milk and may harm a nursing baby.

Common side effects include weight gain, movement disorders, dizziness, feeling tired, constipation, and dry mouth. The first-line psychiatric treatment for schizophrenia is antipsychotic medication; with olanzapine being one such medication. National Institute for Health and Care Excellence, the British Association for Psychopharmacology, and the World Federation of Societies for Biological Psychiatry suggest that there is little difference in effectiveness between antipsychotics in prevention of relapse, and recommend that the specific choice of antipsychotic be chosen based on a person's preference and the drug's side effect profile. Agency for Healthcare Research and Quality concludes that olanzapine is not different from haloperidol in the treatment of positive symptoms and general psychopathology, or in overall assessment, but that it is superior for the treatment of negative and depressive symptoms. In a comparison of 15 antipsychotic drugs in schizophrenia, olanzapine was ranked third in efficacy.

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Analyses of seventeen placebo-controlled trials modal duration of 10 weeks, largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1. The chemical designation is 2-methyl 4-methylpiperazinyl H -thieno benzodiazepine. Each tablet contains olanzapine equivalent to 2. Inactive ingredients are carnauba wax, crospovidone, hydroxypropyl cellulose, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, and other inactive ingredients. Efficacy was established in three clinical trials in adult patients with schizophrenia: two 6-week trials and one maintenance trial. In adolescent patients with schizophrenia ages, efficacy was established in one 6-week trial.

Find out why Zyprexa Olanzapine is prescribed, side effects of Zyprexa, Zyprexa warnings, effects of Zyprexa during pregnancy, more - in plain English. Zyprexa helps manage symptoms of schizophrenia, the manic and mixed phases of bipolar disorder, and other psychotic disorders. Zyprexa may also be used with lithium or valproate for short-term treatment of acute manic episodes of bipolar disorder. Zyprexa is thought to work by opposing the action rosuvastatin crestor 20 mg serotonin and dopamine, two of the brain's major chemical messengers. The drug is available as Zyprexa tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid. At the start of Zyprexa therapy, the drug can cause extreme low blood pressure, increased heart rate, dizziness, and, in rare cases, a tendency to faint when first standing up.

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Olanzapine is a dopamine Zyprexa 3 mg 1, D 2, D 4, 5-HT 2, histamine- 1- and muscarinic-receptor antagonist. Acute myocardial infarction; bradycardia; recent heart surgery; severe hypotension; sick sinus syndrome; unstable angina. An ECG may be required, particularly if physical examination identifies cardiovascular risk factors, personal history of cardiovascular disease, or if the patient is being admitted as an inpatient. See also Prescribing in the elderly. Bone-marrow depression; hypereosinophilic disorders; low leucocyte count; low neutrophil count; myeloproliferative disease; paralytic ileus.

Background: Clinicians need to know the right antipsychotic dose for optimized treatment, and the concept of dose equivalence is important for many clinical and scientific purposes. Methods: We refined a method presented in, which was based on the minimum effective doses found in fixed-dose studies. To qualify for the minimum effective dose, a dose had to be significantly more efficacious than placebo in the primary outcome of at least one randomized, double-blind, fixed-dose trial. In a sensitivity analysis, 2 positive trials were required. The minimum effective doses identified were subsequently used to derive olanzapine, risperidone, haloperidol, and chlorpromazine equivalents. For amisulpride and zotepine, reliable estimates could not be derived.

While doctors often increase the dose of an antipsychotic when there is insufficient response, there is limited evidence that this intervention is any better than waiting longer on the lower dose. The completion rate was significantly lower in the increment group than in the continuation group As a general strategy, patients with schizophrenia failing to respond to moderate antipsychotic doses may not benefit from an increase in dose. Frequently asked questions. My Bibliography Add to Bibliography. Generate a file for use with external citation management software.