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Zyvox comes from the first new class of antibiotics -- the oxazolidinones -- to be introduced in 35 years. Patients with pneumonia, zyvox oral cost skin and soft tissue infections, urinary tract infections or bacteremia caused by known or suspected methicillin-resistant staphylococci were included in the initial study. Participants were treated with Zyvox mg IV twice daily with an option to switch to mg oral Zyvox twice daily or vancomycin 1g IV twice daily. There were no overall differences in the total number of days patients received treatment between the Zyvox and vancomycin groups 13 days vs. Comparable efficacy and safety were observed in the two treatment arms. Zyvox is indicated for the treatment of infections caused by susceptible strains of designated organisms in adults and children, including patients with complicated skin and skin structure infections caused by Staphylococcus aureus both methicillin-resistant and -susceptible strains, Streptococcus pyogenes and Streptococcus agalactiae. It has not been studied in the treatment of diabetic foot and decubitis ulcers.
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The cost implications of using intravenous and oral linezolid instead of intravenous vancomycin in Canadian clinical practice have not been examined. Health care resource use associated with linezolid and vancomycin therapy was estimated for patients in Quebec, based on expert opinion.
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