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Rationale: There is currently no effective pharmacological treatment for obstructive sleep apnea OSA. Recent investigations indicate that drugs with noradrenergic and antimuscarinic effects improve genioglossus muscle activity and upper airway patency during sleep. Objectives: We aimed to determine the effects of the combination of a norepinephrine reuptake inhibitor atomoxetine and an antimuscarinic oxybutynin on OSA severity apnea—hypopnea index ; primary outcome and genioglossus responsiveness secondary outcome in people with OSA. Methods: A total of 20 people completed a randomized, placebo-controlled, double-blind, crossover trial comparing 1 night of 80 mg atomoxetine plus 5 mg oxybutynin ato—oxy to placebo administered before sleep. The AHI and genioglossus muscle responsiveness to negative esophageal pressure swings were measured via in-laboratory polysomnography.

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