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The combination of antiemetic drugs could be a solution to prevent severe postoperative nausea and vomiting PONV. The aim of this randomized double blind, dose-ranging study was to determine the minimum single effective dose of dexamethasone combined with ondansetron for the prevention of PONV in patients undergoing laparoscopic cholecystectomy. One hundred eighty patients were allocated randomly to one of six groups to receive saline P group, ondansetron 4 mg O group, or ondansetron 4 mg and dexamethasone at doses of 2 mg OD2 group, 4 mg OD4 group, 8 mg OD8 group, and 16 mg OD16 group. A standardized general anesthetic was used. All episodes of PONV during the intervals of zero to six hours, hr and hr after surgery were evaluated using a numeric scoring system. Mean visual analogue scale pain scores at rest and on movement, the time to first demand of analgesia, total analgesic consumption in 12 hr epochs, duration of hospital stay, and side effects were recorded.