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Etodolac works by reducing the levels of hormones that cause inflammation and pain in the body. Etodolac may also be used for other purposes. Some examples of the off-label uses of this drug include the relief of

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It was patented in and approved for medical use in They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Post-marketing studies demonstrated that etodolac inhibition of cyclooxygenase is somewhat COX-2 selective similar to celecoxib and other COX-2 inhibitors. The R- enantiomer of etodolac is inactive against COX enzymes, but inhibits beta-catenin levels in hepatoma cells.

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