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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Also available as Eldepryl 10 mg Tablets.
Selegiline acts as a monoamine oxidase inhibitor, and increases levels of monoamine neurotransmitters in the brain. At typical clinical doses, selegiline is a selective and irreversible inhibitor of monoamine oxidase B MAO-B, increasing levels of dopamine in the brain. In larger doses, it loses its specificity and also inhibits MAO-A, increasing levels of serotonin, norepinephrine, and dopamine in the brain.
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But supplies of selegiline are likely depleted. We eldepryl 5 mg tablet that moving people from one treatment to another due to a change in funding can be difficult. We have received clinical advice that rasagiline may be a suitable alternative for people to be transitioned to.
In children and young eldepryl 5 mg tablets, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial months of therapy and dosage adjustments. Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.
Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. It is best to take the capsules or tablets in the morning during breakfast and lunch.
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Selegiline is used to eldepryl 5 mg tablet control the symptoms of Parkinson's disease PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance in people who are taking levodopa and carbidopa combination Sinemet. It works by increasing the amount of dopamine a natural substance that is needed to control movement in the brain. The capsule is usually taken twice a day with breakfast and with lunch. Take selegiline exactly as directed.
Government of Newfoundland and Labrador. Strength This refers to the amount of the active medicinal ingredient e. Benefit Status Open - Drugs which are reimbursed with no criteria or prior approval.
This is a quick reference drug monograph for the monoamine oxidase inhibitor MAOl, type B, selegiline Eldepryl, Zelapar. Only your health care provider has the knowledge and training to decide which medicines are right for you. Specialty Pharmacy Cost: 2. Long-term Care Pharmacy Cost: 2.
As your eldepryl 5 mg tablets improve and your body movements become easier, be careful not to overdo physical activities. Do not stop taking this medicine without speaking with your doctor first - stopping suddenly can cause problems. Selegiline works by increasing the effect of dopamine in the brain, and this helps to ease these typical symptoms.
An alternative MAO-B inhibitor, rasagiline, may be a suitable agent for new patients or those transitioning from selegiline. This resource provides advice on prescribing and supplying rasagiline, which is currently funded but not yet approved by Medsafe.
No overdosage cases known. Pethidine - serious, sometimes fatal reactions with concomitant use or in patients who have discontinued MAOl therapy and are then started on Pethidine within two weeks of discontinuation.
Serious drug interactions can occur when certain medicines are used together with selegiline. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Authored by Dr. Mark G. Stavros, MD