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Abstract Olanzapine OLZ is an antipsychotic drug used in the treatment of schizophrenia. Journal of Pharmacology and Experimental Therapeutics Vol. The Roles of Oleoylethanolamide in Hepatic Glycometabolism. While effective in reducing psychoses, OLZ causes acute increases in blood glucose. Conversely, hypothalamic activation of AMPK has been suggested to mediate the hyperglycemic effects of olanzapine.

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