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Aminopenicillin similar to amoxicillin; not stable to beta-lactamases of either gram-positive or gram-negative bacteria; used commonly for obstetric infections, otitis media, sinusitis and other infections due to susceptible organisms; oral ampicillin exhibits lower bioavailability and higher incidence of GI effects than amoxicillin. A order ampicillin drug duration of 14 to 21 days is recommended for GBS meningitis or meningitis due to L. Ampicillin in combination with gentamicin is recommended as an alternative to penicillin in the setting of shortage for endocarditis due to highly penicillin-susceptible or resistant Viridans group streptococci and S. Ampicillin is recommended as an alternative to penicillin in the setting of penicillin unavailability for streptococcal endocarditis; treat for 4 weeks for native valve endocarditis NVE and for 6 weeks for prosthetic valve endocarditis PVE. Ampicillin plus an aminoglycoside for 4 weeks is recommended as an alternate therapy for endocarditis due to HACEK microorganisms.
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