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The percentage of patients experiencing adverse events was similar in each treatment group, and resultant discontinuation was rare. The most frequent adverse events associated with ziprasidone were generally mild dyspepsia, nausea, dizziness, and transient somnolence. The results indicate that ziprasidone is effective and well tolerated in the treatment of the positive, negative, and depressive symptoms of an acute exacerbation of schizophrenia or schizoaffective disorder. Ziprasidone 1,2-Benzisothiazolyl piperazinylethylchloroindolinone hydrochloride hydrate is a novel antipsychotic with high affinity for dopamine D 2 and D 3, serotonin 5HT 2A, 5HT 2C, and 5HT 1D receptors and high affinity for the 5HT 1A receptor, where it acts as a potent agonist Seeger et al. In vitro functional dopamine receptor antagonism by ziprasidone has been demonstrated by concentration-dependent blockade of effects induced by a D 2 agonist, quinpirole inhibition of forskolin-stimulated adenylate cyclase Seeger et al. After systemic administration, ziprasidone produced relatively modest increases in dopamine metabolites as compared with haloperidol Seeger et al. The inhibition by ziprasidone of the firing of dorsal raphe 5HT neurons was antagonized by the selective 5HT 1A antagonist WAY, as was the elevation of extracellular levels of dopamine in the medial frontal cortex, establishing in vivo 5HT 1A agonist activity Reynolds et al.

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The medicine is in a class of drugs known as atypical antipsychotics, which works by altering the activity of neurotransmitters in the brain. It's manufactured by, Inc. Geodon includes a black-box warning highlighting the risk of death in older adults with dementia. Geodon may make it harder for your body to cool down if it gets hot. Use caution and drink plenty of fluids if you're exposed to hot weather or if you plan to exercise. This medicine may increase the amount of prolactin a hormone in your blood.

Safety: Geodon 60 mg QTc interval prolongation; consider monitoring ECG during therapy baseline and after dose increases, particularly in patients with risk factors for QTc prolongation eg, preexisting QT prolongation, other cardiovascular disease, uncorrected electrolyte abnormalities, concurrent use with other drugs that prolong QT interval Ref. Some experts recommend checking baseline ECG in patients with schizophrenia, regardless of risk factors Ref. Other agents are used preferentially in agitation associated with certain intoxications eg, anticholinergic substances, stimulants or alcohol withdrawal. Depending on presentation, may combine with a benzodiazepine Ref. For cooperative patients able to take oral medication, use an alternative antipsychotic that does not need to be taken with a meal.

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All FDA black box warnings are at the end of this fact sheet. Ziprasidone is a medication that works in the brain to treat schizophrenia. Ziprasidone rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include This medication sheet will focus primarily on schizophrenia.

Geodon ziprasidone is an antipsychotic medication. Geodon is used to treat schizophrenia and the manic symptoms geodon 60 mg bipolar disorder manic depression in adults and children who are at least 10 years old. It is available as an oral by mouth treatment as an injection. You should not use Geodon if you have a heart rhythm disorder, a history of long QT syndrome, uncontrolled heart failure, if you have recently had a heart attack, or if you are allergic to ziprasidone. This list is not complete and there may be other drugs that should not be taken at the same time as Geodon. If you become pregnant while taking Geodon, do not stop taking it without your doctor's advice.

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Older adults with dementia may also have a greater chance of having a stroke or mini-stroke during treatment. Ziprasidone is not approved by the Food and Drug Administration FDA for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking ziprasidone. Ziprasidone is used to treat the symptoms of schizophrenia a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions. It is also used to treat episodes of mania frenzied, abnormally excited or irritated mood or mixed episodes symptoms of mania and depression that happen together in patients with bipolar disorder manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods. It works by changing the activity of certain natural substances in the brain.

You should not take GEODON if you have certain kinds of heart conditions that change your heart rhythm, a recent heart attack, heart failure, or take certain medicines known to change heart rhythm. These could be a sign of tardive dyskinesia TD, a potentially permanent condition whose risk increases with the length of treatment, but which can also occur after brief periods at low doses. During these six months, 5. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient. Have a question about the Geodon Savings Card? Speak to a live representative at

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional. All medicines and poisons in Australia are categorised by how they are made available to the public. Medicines with a low safety risk are usually less tightly controlled than medicines with a higher safety risk. If you are over 65 years of age, there may be specific risks and recommendations for use of this medicine. Please discuss your individual circumstances with your pharmacist, doctor or health professional.