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Oxybutynin has been used for years in the treatment of urinary incontinence. This medication has been effective in reducing the frequency and total number of incontinent episodes. One of the most common anti-cholinergic side effects of immediate-release oxybutynin is dry mouth, which is one of the main reasons patients stop taking this medication. Patients with a history of urge incontinence or mixed incontinence with a primary urge component who experienced at least six urge incontinent episodes per week when not taking medications were eligible to participate in the study. Of the patients screened, were enrolled. One group received controlled-released oxybutynin starting at a dosage of 5 mg per day and titrated upward to a maximum dosage of 30 mg per day. Patient diaries indicating the number of weekly urge episodes served as the efficacy component for both regimens.
Overactive bladder OAB is a common condition which negatively impacts the quality of life of afflicted patients. This can result in alterations in social interactions at home, in the workplace and in the community, often leading to depression and poor self esteem as well as loss of productivity. Traditional mainstays of treatment include both behavioral therapy and pharmacotherapy. Nevertheless, bothersome side effects in addition to thrice daily dosing often led to treatment cessation which raised the question that patients may actually prefer to live with their OAB symptoms rather than incur side effects or complex dosing schemes. The pathophysiology of OAB is not completely understood and likely there are multiple pathways leading to the end disease state. Normal bladder storage and micturition function requires precise neurologic and muscular coordination; possible alterations at the myogenic, mucosal and neurogenic levels may contribute to the condition. While causative myogenic and mucosal alterations would take place at the end organ bladder and urethra, adverse changes in bladder innervations may occur at the peripheral or central level.
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Oral antimuscarinic for overactive bladder or urinary incontinence; quaternary amine; does not cross the blood-brain barrier; less CNS side effects expected versus oxybutynin. Initially, 20 mg PO twice daily. May titrate downward to ditropan 20mg 60 mg PO once daily at bedtime if anticholinergic side effects are intolerable. It appears that no dosage adjustments are needed; however, per the manufacturer, caution is advised with administering trospium to patients with moderate or severe hepatic impairment. Tablets: Administer trospium at least 1 hour before meals or on an empty stomach.
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In general, dosage adjustment may proceed at approximately weekly intervals. In some cases, angioedema occurred after the first dose.
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Trospium chloride is used to treat overactive bladder. However it doesn't cause central nervous system side effects like other drugs of its class.
Trospium is used to treat overactive bladder and symptoms of urinary incontinence, frequency, and urgency. You should not take this medicine if you are allergic to trospium, or if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive system, or if you are unable to urinate. Avoid drinking alcohol within 2 hours before or after you take trospium. Drinking alcohol can increase certain side effects of trospium. This medication may cause blurred vision and may impair your thinking ditropan 20mg 60 reactions.
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