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The incidence of cerebral infarction and poor outcome in patients with aneurysmal subarachnoid hemorrhage aSAH is reduced by oral nimodipine but acute effects of the drug may include a significant decrease in mean arterial blood pressure MAP. A dose reduction or discontinuation of the drug is recommended if recurrent MAP drops occur. The aim of our study was to evaluate the frequency and clinical significance of nimodipine dose modifications in patients suffering buy zantac uk aSAH. Dose reduction and discontinuation occurred with a significantly higher frequency in patients in poor clinical condition. Application of the full nimodipine dosage decreased the risk of unfavorable clinical outcome in multivariate analysis OR 0.

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Calcium antagonists reduce the proportion of patients with poor outcome and ischemic neurological deficits after aneurysmal subarachnoid hemorrhage aSAH. The evidence for nimodipine is not beyond every doubt, but given the potential benefits and modest risks associated with this treatment, against the background of a devastating natural history, oral nimodipine 60 mg every 4 h buys nimotop nimodipine indicated in patients with aSAH. Counteractive measures, including the use of intravenous vasopressors, application of fluid bolus, or a reduction in oral nimodipine dosage 30 mg every 2 h, may be necessary to overcome profound repetitive hypotensive episodes.

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