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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Repaglinide is used to control type 2 diabetes in adults as an add-on to diet and exercise: treatment is usually started if diet, exercise and weight reduction alone have not been able to control or lower your blood sugar. Repaglinide should not be taken if you have a severe liver disease see Do not take Repaglinide tablets. Repaglinide may not be suitable for you.

Chandni Chowk, Delhi Building No. Jaripatka, Nagpur House No. Singanpore, Surat Plot No. Gujranwala Town, Delhi A, G. How repaglinide worksRepaglinide is an anti-diabetic medication.

Type 2 diabetes is a disease in which your pancreas does not make enough insulin to control the sugar in your blood or where your body does not respond normally to the insulin it produces. The warning prandin 2mg tabs of too high blood sugar appear gradually. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Watch for signs of a hypo. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

Manufacturer advises patients exposed to stress including fever, trauma, infection or surgery may require treatment interruption and temporary replacement with insulin to maintain glycaemic control. Cardiovascular disease; constipation; hepatic function abnormal; vasculitis; vision disorders; vomiting. Drivers need to be particularly careful to avoid hypoglycaemia and should be warned of the problems. Drug action Drug action For repaglinide Repaglinide stimulates insulin secretion.

Repaglinide is an oral medication your doctor may prescribe to regulate blood sugar level control in the treatment of your type 2 diabetes mellitus. It belongs to a class of medications known as meglitinides, or simply Glinides for short. If needed, other diabetes medicines can be sometimes prescribed together with it. It should be used in addition to a healthy diet and regular exercise.

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At such times, it may be necessary to discontinue repaglinide and treat with insulin on a temporary basis. Repaglinide, like other insulin secretagogues, is capable of producing hypoglycaemia. Combination with insulin secretagogues. The blood glucose-lowering effect of oral hypoglycaemic medicinal products decreases in many patients over time.

This may be due to progression of the severity of the diabetes or to diminished responsiveness to the medicinal product. This phenomenon is known as secondary failure, to distinguish it from primary failure, where the medicinal product is ineffective in an individual patient when first given. Adjustment of dose and adherence to diet and exercise should be assessed before classifying a patient as a secondary failure.

Use of repaglinide in case of secondary failure to insulin secretagogues has not been investigated in clinical trials. However, the benefit risk profile remains to be established when comparing to other combination therapies. The use of repaglinide might be associated with an increased incidence of acute coronary syndrome e.

Repaglinide should be used with caution or be avoided in patients receiving medicinal products which influence repaglinide metabolism see section 4. Consequently metabolism, and by that clearance of repaglinide, may be altered by substances which influence these cytochrome P enzymes via inhibition or induction. Special care should be taken when inhibitors of both CYP2C8 and 3A4 are co-administered simultaneously with repaglinide. Based on in vitro data, repaglinide appears to be a substrate for active hepatic uptake organic anion transporting protein OATP1B1.

Co-administration of gemfibrozil mg twice daily, an inhibitor of CYP2C8, and repaglinide a single dose of 0. Half-life was prolonged from 1. The concomitant use of gemfibrozil and repaglinide is contraindicated see section 4. Co-administration of trimethoprim mg twice daily, a moderate CYP2C8 inhibitor, and repaglinide a single dose of 0. This lack of pharmacodynamic effect was observed with a sub-therapeutic dose of repaglinide. Since the safety profile of this combination has not been established with dosages higher than 0.

It cannot be excluded that other inducers, e. The effect of ketoconazole, a prototype of potent and competitive inhibitors of CYP3A4, on the pharmacokinetics of repaglinide has been studied in healthy subjects. Co-administration of mg ketoconazole increased the repaglinide AUC and C max by 1. Co-administration of mg itraconazole, an inhibitor of CYP3A4, has also been studied in healthy volunteers, and increased the AUC by 1.

No significant effect on the glucose level in healthy volunteers was observed. In an interaction study in healthy volunteers, co-administration of mg clarithromycin, a potent mechanism-based inhibitor of CYP3A4, slightly increased the repaglinide AUC by 1. The exact mechanism of this interaction is not clear. In a study conducted in healthy volunteers, the concomitant administration of repaglinide a single dose of 0. Since the interaction has not been established with dosages higher than 0.

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Government of Newfoundland and Labrador. Strength This refers to the amount of the active medicinal ingredient e.

Prandin generic cost different for 1 mg than 2mg Benefit Details. See individual insulin cost-sharing below. Drugs Starting with Letter R.

Adjunct to prandin 2mg tab and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Concomitant clopidogrel: avoid; if unavoidable, initiate 0. Concomitant cyclosporine: max 6mg daily. Not for use with NPH-insulin possible myocardial ischemia.

Strength This refers to the amount of the active medicinal ingredient e. Benefit Status Open - Drugs which are reimbursed with no criteria or prior approval. Note: a drug may have limitations that restrict usage. Limitations Drugs which are restricted to those individuals who meet the defined restriction requirements. Limitation based on age such as children under 12 years of age.

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