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Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients treated with an aromatase inhibitor and an LH-releasing hormone analogue in particular. Calibrators, quality controls QC, or serum samples were spiked with isotope-labeled internal standard and purified by liquid-liquid extraction. QCs at 6 levels made from pooled patient sera were used to validate the accuracy, sensitivity, and precision of the method.
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Hormone replacement therapy may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs and legs. Tell your doctor if you smoke and if you have or have ever had breast lumps or cancer; a heart attack; a stroke; blood clots; high blood pressure; high blood levels of cholesterol or fats; or diabetes. If you are having surgery or will be on bedrest, talk to your doctor about stopping estrogen and progestin at least 4 to 6 weeks before the surgery or bedrest. Combinations of estrogen and progestin are used to treat certain symptoms of menopause. Estrogen and progestin are two female sex hormones.
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Estrogens are hormones produced by the body. Among other things, estrogens help develop and maintain female organs.
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Authored by Dr. Mark G. Stavros, MD