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Domperidone is a peripheral dopamine D 2 -receptor antagonist with gastrokinetic and anti-emetic properties. It is used in the treatment of symptoms of nausea and vomiting of variable origin. It exerts its actions via inhibition of dopamine receptors in the human gut, and in the chemoreceptor trigger zone CTZ, which lies outside the blood-brain barrier in the area postrema. The active substance is available as domperidone and as domperidone maleate. An overall summary of the scientific evaluation is provided together with the amended summary of product characteristics.
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