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Statins such as Crestor rosuvastatin and Lipitor atorvastatin are cornerstones in the management of cholesterol and the prevention of cardiovascular disease. Although these two drugs are in the same class, they offer different potencies, side effects, and dosages. This article aims to provide a more profound understanding of the mechanism of action of these statins and the reasons behind their differing potencies. This enzyme plays a key role in the production of cholesterol. As a response, the liver cells increase the number of LDL receptors on their surface to absorb more LDL from the bloodstream.
Lipitor can also raise the levels of HDL cholesterol good cholesterol in your blood. The drug is sometimes prescribed to people with an existing heart condition to lower their risk of experiencing a heart attack or other cardiac event. Additionally, Lipitor may be prescribed as a preventive drug for people with type 2 diabetes, high blood pressure hypertension, a history of smoking, or other conditions that could increase their risk for heart complications. In, the company denied liability for lawsuits by women who claimed that Lipitor gave them type 2 diabetes, stating that the women may have other risk factors that make them vulnerable to the disease, such as high blood pressure or obesity.
Lipitor 5mg patients treated with just 5 mg of atorvastatin, investigators also noted a significant progression of atherosclerotic plaque in the abdominal aorta, whereas vessel-wall thickness and vessel-wall area in the thoracic aorta increased slightly, but not significantly. This may be the best way to look at regression, as we can interrogate different vessel beds and see how they react to lipid-lowering treatment. The study was a prospective, randomized, open-label trial designed to measure the effects of high-dose atorvastatin vs low-dose atorvastatin on atherosclerotic plaque in the thoracic and abdominal aortas of asymptomatic hypercholesterolemic patients. Repeat MRI was scheduled after 12 months of treatment to observe changes in the atherosclerotic aortic plaque.
Some simple steps can help minimize or avoid muscle problems from Crestor and other cholesterol-lowering drugs. All drugs have side effects. The trick is to weigh the potential for serious side effects against the gain you can get from the medication.
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Initially, 10 to 20 mg PO once daily. The daily dose may be given at any time during the day and without regard to meals. After dosage initiation or titration, lipid concentrations should lipitor 5mg analyzed within two to four weeks. In general, geriatric patients may have an increased cholesterol-lowering response to HMG-CoA reductase inhibitors.
Efficacy of atorvastatin when not administered daily. After a week diet period, atorvastatin was initiated at a dose of 10 mg per day. The percentage variation in costs was the parameter to evaluate the saving. Forty one patients remained throughout the study and had their weekly dosage reduced.
There is evidence favoring primary prevention with statins for high-risk patients. Patients with coronary disease should be treated with statins to achieve an low-density lipoprotein cholesterol LDL-C 2. The percentage of patients who obtain the target Lipitor 5mg level of 3. Steady-state statin drug levels may be achieved in a few days, but steady-state LDL-C reductions take several weeks to achieve, and after discontinuation, it takes several weeks before the cholesterol level returns to baseline. The cholesterol-lowering action of alternate-day statins is as effective as daily dosing in many individuals.
There is very little difference in the medicinal properties of statins Crestor rosuvastatin and Lipitor atorvastatin. Crestor generic name Rosuvastatin and Lipitor generic name Atorvastatin, are both statins, i. They also helps raise good cholesterol HDL in the blood.
This medicine is also given to lessen the risk of heart attack and stroke. It may also help a person with heart disease or someone at risk of developing heart disease. It works by slowing the production of cholesterol in your body.
Crestor rosuvastatin: What's the difference? What are Lipitor atorvastatin and Crestor lipitor 5mg Reducing LDL cholesterol slows progression and may reverse coronary artery disease. Lipitor also raises HDL good cholesterol that protects against coronary artery disease and reduces the concentration of triglycerides fats in the blood. High blood concentrations of triglycerides are also associated with coronary artery disease.
This material is provided for educational lipitor 5mg only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
What is Atorvastatin Calcium? Atorvastatin Brand name: Lipitor is a popular medication prescribed for the treatment of high cholesterol and triglyceride levels in the blood. It is in a class of drugs known as statins, which are used to prevent events associated with cardiovascular disease, such as stroke, heart attack, and angina. Atorvastatin works by reducing the amount of cholesterol that sticks to the walls of your arteries, thus preventing blood flow blockage to the heart, brain, and rest of your body.
Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. Atorvastatin was patented in, and approved for medical use in the United States in The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease: 9. Statins predominantly simvastatin have been trialled in combination with fibrates to manage dyslipidemia in patients who also have type 2 diabetes, and a high cardiovascular disease risk, however, there is limited clinical benefit noted for most cardiovascular outcomes 35 While many short half-lives statin medications should be administered in the evening for optimal effect, atorvastatin can be dosed at any time of day due to its long half-life profile, as long as it is continually dosed once daily at the same time to enhance better adherence.
Authored by Dr. Frederic Kalenscher, MD