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People with Alzheimer's disease often develop cardiac dysfunction of the autonomic nervous system with increased sympathetic and reduced parasympathetic activity. This is reflected in a reduction of HRV associated with an increased mortality. Acetylcholinesterase inhibitors have the potential to further reduce HRV 1,2. We investigated the effects of therapy with galantamine on HRV parameters in 30 Alzheimer's patients. They received a hour ECG Oxford Instruments Medilog AR12, without medication and after 4 and 8 weeks of therapy with a daily dose of galantamine of 8mg at week 4 and 16mg at week 8. The error-free recorded HRV over 24 hours and separate 3-hour observation periods during the day and the night were evaluated. Between the basal measurement and the 8mg dose after 4 weeks of treatment, there were no relevant changes of the HRV parameters in the hour observation period.

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It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. As the disease progresses, patients find it more and more difficult to carry out their normal daily activities. Ask your doctor if you have any questions about why this medicine has been prescribed for you. The reason for this difference is currently not known and may just be due to chance. Your doctor or pharmacist can tell you what to do if you are taking any of these medicines.

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Reminyl XL is indicated for the symptomatic treatment of mild to moderately severe dementia of the Alzheimer type. The tolerance and dosing of galantamine should be reassessed on a regular basis, preferably within 3 months after start of treatment. Maintenance treatment can be continued for as long as therapeutic benefit is favourable and the patient tolerates treatment with galantamine. Discontinuation of galantamine should be considered when evidence of a therapeutic effect is no longer present or if the patient does not tolerate treatment. There is no rebound effect after abrupt discontinuation of treatment e. Switching to Reminyl prolonged-release capsules from Reminyl tablets or Reminyl oral solution.

Advise patients and caregivers to ensure adequate fluid intake during treatment. Administration with food may be helpful to lessen some gastrointestinal side effects. If therapy has been interrupted for more than 3 days, restart at the lowest dosage and titrate as directed to the patient's current dosage. Immediate-release tablets: Administer twice per day, preferably with food e. Extended-release capsules e. Galantamine oral solution Preparation of dose To remove the childproof cap, push the plastic cap on the bottle down while turning the cap counter-clockwise.

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Reminyl 8mg is indicated for the treatment of patients with mild to moderate dementia, including Alzheimer's disease associated with cerebrovascular disease. However, Reminyl can cause some unwanted side effects, so patients need to take the drug exactly as prescribed by the doctor. The ingredient Galantamine hydrobromide in Reminyl is a tertiary alkaloid that is a competitive, selective and reversible inhibitor of acetylcholinesterase. The maximum dose is 8mg twice a day; Patients with moderate hepatic impairment: The starting dose is 8mg every other day. Thereafter, a dose of 8 mg once daily with extended-release capsules was administered for at least 4 weeks. The total daily dose of Reminyl should not exceed 16mg.

Galantamine is prescribed for people who have dementia which is associated with Alzheimer's disease. This would happen every so often, over the span of a few months Galantamine Reminyl In this article About galantamine Before taking galantamine How to take galantamine Getting the most from your treatment Can galantamine cause problems? Is losing your sense of taste and smell a symptom of coronavirus? COVID coronavirus: do you need to disinfect your home?

The originating document has been archived. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. This includes any possible side effects not listed in this leaflet.