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Procyclidine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency. Cardiovascular order kemadrin procyclidine elderly; hypertension; liable to abuse; prostatic hypertrophy; psychotic disorders; pyrexia; those susceptible to angle-closure glaucoma. Anxiety; cognitive impairment; confusion; dizziness; gingivitis; hallucination; memory loss; nausea; rash; vomiting. Drug action Drug action For procyclidine hydrochloride Procyclidine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.
A case of procyclidine abuse is described in which the clinical presentation was indistinguishable from mania. Controlled exposure on the ward to drugs of abuse, including a double-blind comparison with placebo, confirmed that procyclidine caused a manic response in this patient. Do you have any conflicting interests?
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The anticholinergic drugs currently available in the UK include benztropine, benzhexol or trihexyphenidyl hydrochloride, biperiden, orphenadrine and procyclidine. Benztropine has a longer duration of action than the other anticholinergic drugs. The normal inhibition of cholinergic neurotransmission in the caudate and putamen by DA is blocked by AP drugs.
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