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Acquisition of the extracellular tetracycline TC resistance plasmid pAST2 affected host gene expression and phenotype in the oil-degrading soil bacterium, Acinetobacter oleivorans DR1. The host energy burden imposed by replication of pAST2 led to i lowered ATP concentrations, ii downregulated expression of many genes involved in cellular growth, and iii reduced growth rate. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. Plasmids carrying antibiotic resistance genes are one of the primary sources of multidrug resistance in pathogens. TC resistance could be acquired by three known mechanisms: energy-driven efflux pumps, ribol protection proteins, and TC-modifying enzymes.
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Cholera - Vibrio cholerae tetracycline cost. Proposal of a new method of treating the blue epidemic cholera by the injection of highly oxygenized salts into the venous system. The cholera epidemic in Peru. Tetracycline in the treatment of cholera. Antibiotic therapy of cholera.
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A bacterium's fitness relative to its competitors, both in the presence and absence of antibiotics, plays a key role in its ecological success and clinical impact. In this study, we examine whether tetracycline-resistant mutants are less fit in the absence of the drug than their sensitive parents, and whether the fitness cost of resistance is constant or variable across independently derived lines.
Environmental Sciences Europe volume 33, Article number: 64 Cite this article. The influx of tetracycline may annihilate the microbial ecology structure in the environment and pose a severe threat to humans by disturbing the food chain.
Goode, Mahiul Muquit, Gordon J. It is believed, however, that azithromycin may be a more effective treatment in practice, and the purpose of this study was to test that hypothesis. A masked randomized controlled trial was conducted to compare azithromycin and tetracycline under practical operational conditions—i. Single-dose oral azithromycin was a more effective treatment for active trachoma than tetracycline ointment as applied by caregivers. The high cure rate achieved with tetracycline in this study in the absence of supervision and the significantly higher costs of azithromycin, suggest that in the absence of donation programs, switching routine treatment from tetracycline to azithromycin would not be a good use of resources. Methods Results Discussion.
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