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However, there have been multiple cases of OSP-induced acute kidney injury AKI with defining histologic features on biopsy. This clinicopathologic entity has been referred to as acute phosphate nephropathy. In, the FDA issued another warning that using more than one dose in 24 hours of OSP to treat constipation can cause rare but serious harm to the kidneys and heart, and even death 15. AKI associated with an increased phosphate load has also been described in tumor lysis syndrome, especially with alkalinization of the urine by bicarbonate-containing intravenous IV fluids.
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Authored by Dr. William M Klein, MD