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Elimination times permit a further classification into short-acting tetracycline, oxytetracycline, and chlortetracycline, intermediate-acting demethylchlortetracycline and methacycline, and long-acting doxycycline and minocycline. The tetracyclines are stable as dry powders but not in aqueous solution, particularly at higher pH ranges 7—8. Doxycycline and minocycline exhibit the greatest liposolubility and better penetration of bacteria such as Staphylococcus aureus than does the group as a whole. This may contribute to their efficacy in treatment of gingival diseases that may be associated with bacterial glycocalyx. Tigecycline is a glycylcycline derivative of minocycline; its large side chain decreases the risk of resistance.
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