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Background: Clopidogrel is one of the most commonly prescribed medications because of its ability to improve clinical outcomes for a broad range of cardiovascular conditions. After patent protection expired for Plavix in, many healthcare systems adopted generic clopidogrel as a strategy to reduce healthcare costs. Methods and results: We conducted a population-based observational study to determine whether generic clopidogrel was noninferior to Plavix. The effect of clopidogrel on the hazard of clinical outcomes was estimated using a Cox proportional hazards model within the propensity-weighted cohort using Plavix as a reference. Our study included 24 patients with ACS, 12 were prescribed Plavix and 11 were prescribed generic clopidogrel at naprosyn 440 mg discharge. Keywords: acute coronary syndrome; clopidogrel; hospitalization; ischemic attack, transient; propensity score.

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