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What are ACE inhibitors, and how do they work mechanism of action? Angiotensin II is a very potent chemical produced by the body that primarily circulates in the blood. It causes the muscles surrounding blood vessels to contract, thereby narrowing the vessels. The narrowing of the vessels increases the pressure within the vessels causing increases in blood pressure hypertension. Angiotensin converting enzyme inhibitors ACE inhibitors are medications that slow inhibit the activity of the enzyme ACE, which decreases the production of angiotensin II.
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