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A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid see mesalamine released in the colon.
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In the gut sulfasalazine is broken down by the normal gut bacteria into two parts: one part a sulphonamide antibiotic which kills harmful bacteria; and a second part which acts to reduce the process driving inflammation as well as helping to control the overactive immune system. It is frequently prescribed in combination with methotrexate.
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