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People who take nonsteroidal anti-inflammatory drugs NSAIDs other than aspirin such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as naproxen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes.

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Ernst, clinical professor at the University of Iowa College of Pharmacy and researcher on blood pressure variability, told Healthline. Therefore, they are not usually used as a monotherapy, but are usually reserved for adding to other antihypertensives when the existing regimen fails to achieve the goal blood pressure. Prior research from revealed a link between large variations in blood pressure and increased mortality risk.