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In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists VKA and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke. Since higher doses of ASA were associated with higher bleeding risk it is recommended that the dose of ASA should not be higher than mg. Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks. The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting see section 5. ASA mg daily should be initiated and continued in combination with clopidogrel see section 5. Therapeutic experience is limited in patients with moderate hepatic disease who may have bleeding diatheses see section 4.
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